Table 4.

Multivariable model for loss of glycemic control during 2004-2014 using baseline (randomization) predictors identified via backward stepwise elimination

Multivariable model with baseline risk factors	OR	95% CI	Wald chi-square	P value
C-peptide index (ng/mL per mg/dL)	0.48	0.35-0.66	21.5	< 0.0001
HbA1c (%)	1.89	1.30-2.75	11.0	0.0009
Proinsulin to insulin ratio (pM/µU)	1.52	1.15-2.02	8.5	0.003
Maternal history of diabetes	1.51	1.00-2.31	3.7	0.05

Odds ratios (95% CI) from multivariable logistic regression model. Variables entered in the model: duration of diabetes, maternal history of diabetes, maternal diabetes during pregnancy, HbA1c, proinsulin to insulin ratio, C-peptide index, and C-peptide oDI. The significant covariates (P < 0.05) remaining after the backward stepwise elimination are shown in the table. Covariates are listed in order of significance as indicated by the Wald chi-square value. There were no multicollinearity issues identified (all VIF values < 10).