. 2022 Nov 8;15:951–957. doi: 10.2147/PGPM.S377210

Table 3.

Summary of Significant Haplotype Findings

Phenotype	Gene	p value	STAT	Allele Combination	Polymorphisms in Haplotype
Efficacy	CES1	0.02	5.35	TCCCATC	rs2244613\|rs2302722\|rs2307235\|rs2307240\|rs8192935\|rs8192950\|rs9921399
Side-Effects	CES1	0.03	4.70	TCCCGGT	rs2244613\|rs2302722\|rs2307235\|rs2307240\|rs8192935\|rs8192950\|rs9921399
Somnolence	SLC6A2	0.05	3.85	GGTTACCG	rs1861647\|rs1992303\|rs2242446\|rs36021\|rs36029\|rs3785143\|rs3785152\|rs5569
Aggressivity	CES1	0.05	3.98	TACCATC	rs2244613\|rs2302722\|rs2307235\|rs2307240\|rs8192935\|rs8192950\|rs9921399

Abbreviations: STAT, stat coefficient statistic considering covariates age, gender and dose; p, significance p value.