Figure 4.

The diagnostic efficacy of ARG classifier in multi-transcriptome datasets. (A–H) ROC curves analyzed the diagnostic accuracy of ARG classifier in multiple datasets and time points. (A) GSE54514 datasets; (B) GSE57065 datasets; (C) GSE65682 datasets; (D) GSE69063 datasets; (E) GSE69528 datasets; (F) GSE95233 datasets; (G) GSE131761 datasets; (H) GSE154918 datasets. (I and J) Comparison of the ARG scores between sepsis and SIRS in GSE63042 datasets (I), uncomplicated Infection in GSE154918 datasets (J). p value was calculated using the Wilcoxon test. (K) Comparison of the ARG scores between sepsis, healthy control and anaphylaxis in GSE69063 datasets. p value was calculated using the Kruskal–Wallis test. (L) Comparison of the ARG scores between sepsis, healthy control and head trauma in GSE69063 datasets. p value was calculated using the Kruskal–Wallis test. (M–P) Principal component analysis based on hub ARGs to distinguish sepsis from SIRS (M), uninfected control (N), anaphylaxis (O), and head trauma (P).

Abbreviation: SIRS, systemic inflammatory response syndrome.