Table 3.
Comparison of Clinical and Labs Characteristics Among Patients with Malignancy Related HLH and Non-Malignancy Related HLH
| Variables | Malignancy Related HLH (N = 22) | Non-Malignancy Related HLH (N = 30) | P-value |
|---|---|---|---|
| Total Effective (%) or Mean (SD) | Total Effective (%) or Mean (SD) | ||
| Gender (male) | 14(64%) | 15(50%) | 0.33 |
| Mean age | 56(21%) | 41(14%) | 0.003 |
| Fever | 22(100%) | 29(97%) | 0.39 |
| Splenomegaly | 16(73%) | 19(63%) | 0.48 |
| Hepatomegaly | 8(36%) | 6(20%) | 0.19 |
| Bicytopenia | 22(100%) | 26(87%) | 0.075 |
| ANC (mm³/µL) | 4106(4361) | 4187(5431) | 0.85 |
| Hb (g/dl) | 8.8(1.6) | 9.5(2.1) | 0.17 |
| Pt (mm³/µL)(SD) | 62,909(57,158) | 75,133(57,828) | 0.45 |
| TG (mg/dl) | 302(119) | 338(134) | 0.32 |
| Fib (mg/dl) | 429(296) | 304(223) | 0.089 |
| Ferritin (µg/L) | 57,051(221,153) | 13,194(14,561) | 0.28 |
| ALAT elevated | 11 (50%) | 23 (77%) | 0,046 |
| ALAT (UI/L) | 99(120) | 421(819) | 0.07 |
| ASAT elevated | 11 (50%) | 23 (77%) | 0,046 |
| ASAT (UI/L) | 119(198) | 319(435) | 0.05 |
| TBIL (mg/dl) | 2.57(6.1) | 3.6(5.5) | 0.51 |
| Albumine (mg/dl) | 29(5.1) | 27(6.3) | 0.33 |
| LDH (UI/L) | 1055(972,100) | 1159(1164) | 0.73 |
| DIC* | 8(36%) | 8(27%) | 0.45 |
| Cortitosteroids | 20(91%) | 22(73%) | 0.11 |
| Etoposide | 6(27%) | 2(7%) | 0.042 |
| Rituximab | 2(9%) | 3(10%) | 0.91 |
| Chemotherapy | 14(64%) | 0 | <0.001 |
| Tocilizumab | 0 | 3(10%) | 0.13 |
| Ruxolitinib | 0 | 1(3%) | 0.39 |
| Overall mortality | 14(64%) | 10(33%) | 0.030 |
| Mortality 30 days | 9(41%) | 4(13%) | 0.023 |
| Mortality 90 days | 2(15%) | 2(8%) | 0.45 |
Notes: *ISTH criteria of DIC was used (DIC was considered if score ≥ 5). Analysis of NK-cell activity, soluble CD25 (sIL-2R), were not performed in patients since these tests were not available on our center.
Abbreviations: ANC, absolute neutrophil count; Hb, hemoglobin; Pt, platelet; Fib, fibrinogen; TBIL, total bilirubin level; TG, triglycerides; DIC, disseminated intravascular coagulation; ALAT, alanine aminotransferase; ASAT, aspartate aminotransferase; LDH, lactate dehydrogenase; ULN, upper limits of normal.