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. Author manuscript; available in PMC: 2023 Apr 1.
Published in final edited form as: J Proteome Res. 2022 Mar 10;21(4):1017–1028. doi: 10.1021/acs.jproteome.1c00906

Figure 2: CPP revealed correlations between 3D alterations and somatic mutations.

Figure 2:

The bipartite network shows the correlation of somatic mutated proteins (oncogens and tumor suppressor genes, blue diamonds) to non-mutated effector proteins (rectangles) in which at least one lysine site is significantly altered in accessibility. The size of nodes scales with connectivity (effector proteins) or number of cell lines in which the protein is mutated (mutated proteins). Edges are colored green in case a decrease in surface accessibility was detected and red in case surface accessibility of the lysine site increased. The line thickness reflects the difference in lysine site accessibility (Δ) between cell lines with and without mutation in the somatically mutated protein.