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. 2021 Sep 9;41(11):2681–2692. doi: 10.1161/ATVBAHA.121.316108

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© 2021 The Authors.

Arteriosclerosis, Thrombosis, and Vascular Biology is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

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Figure. — GPVI (glycoprotein VI) structure and natural variants. A, Schematic presentation of the human GP6 gene structure. The first seven exons encode for the protein extracellular domain, with exons 3-4 encoding for domains D1 and D2, respectively. Exon 8 encodes for the transmembrane and short intracellular region. B, Cartoon showing the human GPVI protein domains with amino acid positions of the nine GPVI natural variants and mutations indicated. C, Representation of crystal structure of the GPVI binding site interacting with CRP (collagen-related peptide). D, Table of reported effects of GPVI variants on protein expression and platelet functions.^16–21 FcR γ indicates Fc receptor γ; and VTE, venous thromboembolism.