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. Author manuscript; available in PMC: 2023 Oct 27.
Published in final edited form as: J Med Chem. 2022 Oct 13;65(20):14015–14031. doi: 10.1021/acs.jmedchem.2c01215

Figure 1: Chemical structures of the 1,4-DHP compounds studied.

Figure 1:

The internal library for testing against Sirtuin isoforms 1, −2, −3 and −5 comprised previously reported (1–24) and newly synthesized (25–43) 1,4-DHP derivatives.