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. Author manuscript; available in PMC: 2023 Oct 27.
Published in final edited form as: J Med Chem. 2022 Oct 13;65(20):14015–14031. doi: 10.1021/acs.jmedchem.2c01215

Scheme 1.

Scheme 1.

Synthesis of Compounds 25–43a

aReagents and conditions: (a) glacial acetic acid, 80 °C; (b) Et3N, aroyl chloride, dry dichloromethane, rt, overnight; (c) stannous chloride dihydrate, 37% HCl, EtOH, rt, overnight.