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. Author manuscript; available in PMC: 2023 Oct 27.
Published in final edited form as: J Med Chem. 2022 Oct 13;65(20):14015–14031. doi: 10.1021/acs.jmedchem.2c01215

Table 3.

Kinetic constants for Sirt5 in the absence and presence of 30.

200 μM compound 30 NAD+ kinetics
Km [uM] vmax [nmol/(mg·min)]
Sirt5 62 ± 13 1.6 ± 0.1
+ 99 ± 20 2.3 ± 0.1