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. Author manuscript; available in PMC: 2023 Oct 27.
Published in final edited form as: J Med Chem. 2022 Sep 23;65(20):13967–13987. doi: 10.1021/acs.jmedchem.2c01197

Figure 3.

Figure 3.

Effect of treatment with compound 22c on infarct volume after ischemic stroke (MCAO). Representative TTC-stained sections showing infarct area (dotted line) in the top panel. Three-day treatment with 22c (5.0 mg/kg/day × 3 days continuous infusion with an Alzet minipump) significantly (*p < 0.05; vs Veh, unpaired t-test) reduced total hemispheric infarct volume in male young adult mice at 3 days after stroke (8–12 weeks old) (n = 5/treatment group = 10 mice; all male). Data are expressed as mean ± S.D.