Figure 6.

Stimulus-evoked S1-mPFC β phase coupling is enhanced after adult injury and is prolonged in animals who experienced ELP. A, An example of simultaneous recording of stimulus evoked LFPs in S1 and mPFC, before (left) and after (right) filtering for phase coupling measurement at θ frequency. B, Peristimulus normalized S1-mPFC PLV at θ frequency following injury, presented as mean ± SEM. C, Comparison of changes in S1-mPFC PLV at θ on the day of injury (D0) and (D) 4 d following injury (D4), expressed as a ratio of normalized PLV (D0/Pre), between groups. E, The enhancement of injury-induced changes in sensory evoked S1-mPFC PLV at θ returned to preinjury level by 4 d (D4) in the NI group, whereas a longer lasting increase in S1-mPFC PLV at θ was found in II. As a bootstrap sampling distribution, 95% confidence intervals are indicated by the ends of the vertical error bars. Statistical analysis was performed using a permutation t test (randomization: 5000). F, Correlations between PWT and stimulus evoked S1-mPFC phase lock θ oscillations. The scatter plots represent correlations between PWT and normalized δ-γ coupling with continuous line as linear regression. Pearson correlation coefficient (R) with significance (p value); *p < 0.05, **p < 0.01. Nonincised adult controls (Con, n = 15), incision in adults without neonatal incision (NI, n = 8) and incision in adults with neonatal incision (II, n = 8).