Table 2.
Direct effects of NR3C1/NR3C2 SNPs, mRNA transcript level and cortisol level on verbal memory in LEGENDE and TREND
| Direct effects on verbal memory in LEGENDE and TREND | ||||
|---|---|---|---|---|
| LEGENDE | TREND* | |||
| Immediate recall (β, CI, p value) | Delayed recall (β, CI, p value) | Immediate recall (β, CI, p value) | Delayed recall (β, CI, p value) | |
| rs56149945 (AG/GG) | − 0.68 [− 1.51, 0.14], p = 0.091 | − 0.46 [− 0.93, − 0.02], p = 0.047 | − 0.14 [− 0.26, − 0.01], p = 0.028 | − 0.23 [− 0.42, − 0.04], p = 0.017 |
| rs2070951 (G) | 0.01 [− 0.30, 0.33], p = 0.94 | − 0.002 [− 0.17, 0.17], p = 0.98 | 0.02 [− 0.03, 0.08], p = 0.45 | 0.02 [− 0.06, 0.09], p = 0.69 |
| NR3C1 transcript* | – | – | − 0.17 [− 0.53, 0.20], p = 0.37 | 0.53 [0.04, 1.02], p = 0.024 |
| NR3C2 transcript* | – | – | 0.10 [− 0.24, 0.43], p = 0.56 | 0.57 [0.10, 1.03], p = 0.016 |
| Cortisol** | – | – | − 0.0004 [− 0.0008, − 0.00008], p = 0.017 | − 0.001 [− 0.001, − 2.5E−7], p = 0.049 |
| Interaction results in TREND subsample | |||
|---|---|---|---|
| Interaction | NAI immediate recall (β, p value) | NAI delayed recall (β, p value) | Hippocampal volume (β, p value) |
| rs56149945 × NR3C1 mRNA | 0.84, p = 0.18 | 2.16, p = 0.013 | − 594, p = 0.023 |
| rs56149945 × cortisol level | − 0.003, p = 0.005 | − 0.002, p = 0.22 | − 1.66, p = 0.012 |
| NR3C1 mRNA × cortisol level | 0.002, p = 0.07 | 0.0003, p = 0.83 | − 1.29, p = 0.012 |
Interaction effects between SNP rs56149945, NR3C1 mRNA transcript level and cortisol level on verbal memory and hippocampal volume in the TREND subsample; significant results are highlighted in italic (p < 0.05 in discovery sample TREND, p < 0.1 in replication sample LEGENDE)
*Gene expression only available in TREND subsample
**Cortisol not available in LEGENDE; β estimates, confidence intervals (CI) and p values; (AG/GG) is the effect genotype group of rs56149945; (G) is the effect allele of rs2070951; linear regression analyses were performed for recall score as outcome