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. 2022 Nov 12;7:144. doi: 10.1038/s41541-022-00571-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — A The binding IgG titers (GMT ± 95%CI) were detected at day 0, day 7, day 14, day 28 and day 35. B Changes in pseduovirus neutralizing antibody titers against prototype SARS-CoV-2 and all five variant of concerns. Day 35 sera of NHP were used following two immunizations with variant vaccine (N = 6). C Cross-reactivity of live virus with SARS-CoV-2 prototype, Beta and Delta strains. D–G Correlation between live virus-neutralizing antibody titers and pseudovirus-neutralizing antibody titers of prototype, Beta, Delta and Omicron strains. Three important parameters from the correlates analysis shown as R-value, P-value and 95% confidence intervals. Shaded areas represent 95% confidence intervals. H Th1-associated cytokines (IFN-γ, IL-2, TNF-α) and Th2-associated cytokines (IL-4, IL-5) secreted from vaccinated monkeys were detected by ELISPOT, data are shown as the Mean ± SD. I % S secific cytokines secreting CD4⁺T cells. J % S secific cytokines secreting CD8⁺T cells, data are shown as the Mean ± SD. Note: *p < 0.05, **p < 0.01, ***p < 0.001; ns, not significant different.