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. 2022 Nov 12;13:6874. doi: 10.1038/s41467-022-34360-z

Fig. 2. CLIMB uncovers interrelationships among hematopoietic cell populations based on CTCF binding patterns.

Fig. 2

a Expected relationship among cell populations. b Heatmaps displaying bi-clusterings of all ChIP-seq data for chromosome 11 based on CLIMB, mash, and Pearson correlation. The columns, corresponding to different cell populations, are ordered according to the dendrogram for each clustering method. The rows, corresponding to each loci, are ordered based on class membership (for CLIMB and mash) and Pearson correlation (for Pearson), respectively. (CH12 and MEL are murine lymphoma and erythroleukemia cell lines, respectively, and thus do not clearly occupy one space in the lineage, though CH12 is most related to B cells, and MEL is a mature erythroid cell type.).