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. 2022 Nov 12;13:6874. doi: 10.1038/s41467-022-34360-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Data from the loci on chromosome 11 that belong to classes of CTCF binding patterns (numbered 1, 4, and 14) identified by CLIMB are shown. The original CTCF ChIP-seq, alongside ATAC-seq and histone modification ChIP-seq data in 4 hematopoietic cell populations reveal differing patterns of epigenetic modifications across cell populations. b Log class means based on CLIMB’s model of CTCF binding patterns for the 3 classes in (a). c Significantly enriched mouse phenotypes (FDR < 0.05 for all) associated with the plotted classes. Class 1, containing loci with CTCF bound in every cell type, is not significantly enriched in any mouse phenotypes. Class 4 is enriched with terms related to T and B cells and the thymus, while class 14 contains terms related to red blood cells and kidney function.