Skip to main content
. 2022 Nov 12;8(1):95. doi: 10.1038/s41537-022-00308-x

Table 2.

Summary of findings across levels of analyses.

Levels of analyses Formal thought disorder (FTD) Auditory verbal hallucinations (AVHs)
Neurocognitive

• A transdiagnostic symptom with a positive and negative form;

• FTD is related to executive functions such as inhibitory control, sustained attention and planning;

• FTD is also related to semantic and pragmatic deficits

• A transdiagnostic symptom, tend to co-occur with FTD;

• AVH is related to impaired monitoring function and likely failure to inhibit unwanted memories

Neuroanatomical

• Functional abnormalities involve inferior frontal gyrus, medial orbital frontal cortex and middle temporal gyri;

• Structural abnormalities in left posterior superior temporal gyrus;

• Structural connectivity studies are less consistent, implicating fibers connecting the language regions and also other fibers

• Abnormal activation during AVHs or auditory tasks in more widespread areas in bilateral superior and middle temporal gyri, inferior frontal gyri, post-central gyri, anterior cingulate cortex insula and cerebellum;

• Structural abnormalities in the bilateral superior temporal gyri;

• Structural connectivity studies mainly reported arcuate and uncinate fasciculus

Neurochemical

• Partially treated by antipsychotics

• NMDA antagonisms elicits transient FTD symptoms and brain activation in the right middle and inferior temporal gyri

• Related to excessive dopamine in the striatum,

• Partially treated by antipsychotics

• Relates to higher level of glutamate/glutamine in the superior temporal gyrus and lateral prefrontal cortex

Genetic • Genes implicated in both language function and schizophrenia mainly involve in early neural development and neurotransmission. Some genes are directly related to structure and function of language regions