Table 2.
Hazard ratios for the incidence of all-cause dementia according to quartile of lipid parameters.
| Quartile of lipid parametersa | n | Events (n) | Follow-up duration (person-years) | Incidence rate (per 1000 person-years) | Hazard ratio (95% confidence interval) | ||||
|---|---|---|---|---|---|---|---|---|---|
| Model 1 | Model 2 | Model 3 | Model 3–1 | Model 4 | |||||
| LDL-C | |||||||||
| Q1 | 1,716,390 | 70,173 | 13,812,376.82 | 5.08044 | 1 (Ref.) | 1 (Ref.) | 1 (Ref.) | 1(Ref.) | 1(Ref.) |
| Q2 | 1,754,964 | 62,949 | 14,259,651.33 | 4.41448 | 0.867 (0.858, 0.876) | 0.906 (0.897, 0.916) | 0.942 (0.932, 0.953) | 0.942 (0.932, 0.953) | 0.956 (0.945, 0.966) |
| Q3 | 1,705,307 | 60,825 | 13,890,566.36 | 4.37887 | 0.859 (0.850, 0.869) | 0.882 (0.872, 0.891) | 0.928 (0.918, 0.938) | 0.928 (0.917, 0.938) | 0.945 (0.935, 0.956) |
| Q4 | 1,706,833 | 69,238 | 13,887,232.24 | 4.98573 | 0.978 (0.968, 0.988) | 0.917 (0.907, 0.927) | 0.969 (0.959, 0.980) | 0.969 (0.959, 0.980) | 0.987 (0.976, 0.998) |
| HDL-C | |||||||||
| Q1 | 1,701,108 | 76,442 | 13,705,008.76 | 5.57767 | 1 (Ref.) | 1 (Ref.) | 1 (Ref.) | 1(Ref.) | 1(Ref.) |
| Q2 | 1,697,679 | 65,701 | 13,787,613.74 | 4.76522 | 0.853 (0.845, 0.862) | 0.939 (0.929, 0.949) | 0.960 (0.950, 0.970) | 0.960 (0.950, 0.970) | 0.958 (0.948, 0.968) |
| Q3 | 1,782,263 | 63,076 | 14,506,544.69 | 4.34811 | 0.779 (0.771, 0.787) | 0.921 (0.911, 0.931) | 0.949 (0.939, 0.959) | 0.949 (0.939, 0.959) | 0.946 (0.936, 0.956) |
| Q4 | 1,702,444 | 57,966 | 13,850,659.56 | 4.18507 | 0.751 (0.743, 0.759) | 0.933 (0.923, 0.943) | 0.965 (0.954, 0.975) | 0.964 (0.954, 0.975) | 0.961 (0.950, 0.971) |
| Triglycerides | |||||||||
| Q1 | 1,698,765 | 48,512 | 13,855,868.15 | 3.50119 | 1 (Ref.) | 1 (Ref.) | 1 (Ref.) | 1(Ref.) | 1(Ref.) |
| Q2 | 1,732,804 | 68,053 | 14,045,373.48 | 4.84523 | 1.384 (1.368, 1.400) | 1.037 (1.025, 1.050) | 1.027 (1.015, 1.039) | 1.027 (1.015, 1.040) | 1.027 (1.015, 1.039) |
| Q3 | 1,727,849 | 76,121 | 13,977,984.87 | 5.44578 | 1.556 (1.538, 1.573) | 1.068 (1.056, 1.080) | 1.048 (1.036, 1.061) | 1.049 (1.036, 1.061) | 1.048 (1.036, 1.060) |
| Q4 | 1,724,076 | 70,499 | 13,970,600.24 | 5.04624 | 1.442 (1.425, 1.459) | 1.145 (1.132, 1.158) | 1.096 (1.083, 1.109) | 1.096 (1.083, 1.109) | 1.096 (1.083, 1.109) |
| Total cholesterol | |||||||||
| Q1 | 1,720,451 | 71,228 | 13,836,389.14 | 5.14787 | 1 (Ref.) | 1 (Ref.) | 1 (Ref.) | 1(Ref.) | 1(Ref.) |
| Q2 | 1,713,211 | 61,467 | 13,928,119.96 | 4.41316 | 0.856 (0.846, 0.865) | 0.924 (0.914, 0.934) | 0.955 (0.944, 0.965) | 0.955 (0.944, 0.965) | 0.967 (0.957, 0.978) |
| Q3 | 1,710,041 | 60,823 | 13,933,296.61 | 4.36530 | 0.846 (0.837, 0.855) | 0.905 (0.895, 0.915) | 0.944 (0.934, 0.955) | 0.944 (0.934, 0.955) | 0.961 (0.950, 0.971) |
| Q4 | 1,739,791 | 69,667 | 14,152,021.04 | 4.92276 | 0.954 (0.944, 0.964) | 0.952 (0.942, 0.962) | 0.994 (0.984, 1.005) | 0.994 (0.983, 1.005) | 1.010 (0.999, 1.021) |
Model 1: unadjusted.
Model 2: adjusted for age and sex.
Model 3: model 2 plus body mass index, diabetes, hypertension, current smoking status, alcohol consumption status, regular exercise, and estimated glomerular filtration rate.
Model 3–1: model 3 plus monthly household income, and Charlson Comorbidity Index.
Model 4: model 3 plus statin use.
LDL-C low-density lipoprotein cholesterol, HDL-C high-density lipoprotein cholesterol.
aLDL-C quartile ranges: Q1 (LDL-C < 94 mg/dl), Q2 (94 mg/dl ≤ LDL-C < 116 mg/dl), Q3 (116 mg/dl ≤ LDL-C < 139 mg/dl), Q4 (LDL-C ≥ 139 mg/dl); HDL-C quartiles: Q1 (HDL-C < 45 mg/dl), Q2 (45 mg/dl ≤ HDL-C < 53 mg/dl), Q3 (53 mg/dl ≤ HDL-C < 63 mg/dl), Q4 (HDL-C ≥ 63 mg/dl); triglyceride quartiles: Q1 (triglyceride < 80 mg/dl), Q2 (80 mg/dl ≤ triglyceride < 115 mg/dl), Q3 (115 mg/dl ≤ triglyceride < 169 mg/dl), Q4 ( triglyceride ≥ 169 mg/dl); and total cholesterol quartiles: Q1 (total cholesterol < 174 mg/dl), Q2 (174 mg/dl ≤ total cholesterol < 197 mg/dl), Q3 (197 mg/dl ≤ total cholesterol < 222 mg/dl), Q4 (total cholesterol ≥ 222 mg/dl).