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. 2022 Nov 12;8:154. doi: 10.1038/s41531-022-00384-x

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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Graphs representing MMSE score data points and regression lines in the PD group (blue line) and HC group (pink line) as function of plasma p-tau181 concentrations (a) and plasma NfL concentrations (b). *Significant linear regression model, with MMSE scores as dependent variables and plasma NfL as predictor, while adjusting for age, sex and years of education (Standardised β = 0.240, P = 0.027, overall regression model: R2 = 0.152, P = 0.002). MMSE Mini-Mental State Examination, PD Parkinson’s disease, HC healthy controls, pg/mL picograms per millilitre.