Table 2.
Association between baseline plasma p-tau181 (p-tau181 Model) and NfL (NfL Model) and longitudinal MMSE scores.
| Fixed Effects | MMSE | |
|---|---|---|
| Estimate (SE) | P value | |
| p-tau181 Model | ||
| (Intercept) | 28.731 (1.778) | <0.001 |
| Time (years) | −0.226 (0.300) | 0.453 |
| p-tau181 (pg/mL) | −0.101 (0.225) | 0.651 |
| Age | −0.023 (0.024) | 0.350 |
| Sex | −0.499 (0.669) | 0.459 |
| Education | 0.053 (0.059) | 0.377 |
| Time * p-tau181 | −0.097 (0.109) | 0.376 |
| NfL Model | ||
| (Intercept) | 28.667 (1.778) | <0.001 |
| Time (years) | 0.320 (0.372) | 0.393 |
| NfL (pg/mL) | 0.006 (0.029) | 0.827 |
| Age | −0.009 (0.025) | 0.731 |
| Sex | −0.455 (0.658) | 0.494 |
| Education | 0.071 (0.060) | 0.239 |
| Time * NfL | −0.036 (0.015) | 0.020 |
p-tau181 phosphorylated tau 181, NfL neurofilament light chain, MMSE Mini Mental State Examination, SE standard error, pg/mL picogram per millilitre. Bold values denote statistical significance at the P < 0.05 level.