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. 2022 Nov 12;12:19432. doi: 10.1038/s41598-022-22696-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Transcriptome patterns and properties of genes impacted by EMP2 modification. Changes in gene expression across wild type (WT), EMP2 overexpressing (OE), and EMP2 knock down (KD) ARPE-19 cells were queried by the likelihood ratio test. (A) Hierarchical clustering analysis of the top 1000 significant genes (FDR < 0.01) by the degPatterns tool within the DEGreport R package (version 1.26.0) reveals four distinct expression profile groups. (B, C) Enriched biological property gene ontology (GO) terms for group 1 and group 2 cluster genes, respectively. The top 10 GO terms ordered by gene ratio (number of GO term-related genes divided by total number of significant genes) identify angiogenesis and vasculature-related terms as significantly enriched for group 1 genes. Dot color represents the Benjamini–Hochberg adjusted p value for each enriched GO term. All samples were performed in triplicate.