Table 1.
Gene Set Enrichment Analysis was performed on differentially expressed transcripts in ARPE-19 cells with modified EMP2 levels, with the top 10 Go ontology terms from Group 1 (KD < WT < EMP2) shown.
| Description | Count | Genes |
|---|---|---|
| Blood vessel morphogenesis | 48 | ADGRG1/ADTRP/ANGPTL4/ANXA3/B4GALT1/BMPER/CCN2/COL4A1/COL4A2/COL4A3/CTSH/CXCL8/EFNB2/EMC10/EMP2/ENPP2/EPHA2/HDAC7/HEG1/HES1/HIF1A/IL18/ITGA5/ITGAV/JUNB/JUP/LOX/LOXL2/MCAM/MMP2/MYH9/MYOCD/NPPB/PARVA/PLK2/PLXND1/PTGIS/RHOB/SERPINE1/SFRP1/SHB/SPHK1/SULF1/TGFB2/TGFBI/THBS1/TNFRSF12A/UNC5B |
| Angiogenesis | 43 | ADGRG1/ADTRP/ANGPTL4/ANXA3/B4GALT1/BMPER/CCN2/COL4A1/COL4A2/COL4A3/CTSH/CXCL8/EFNB2/EMC10/EMP2/ENPP2/EPHA2/HDAC7/HIF1A/IL18/ITGA5/ITGAV/JUP/LOXL2/MCAM/MMP2/MYH9/NPPB/PARVA/PLK2/PLXND1/PTGIS/RHOB/SERPINE1/SFRP1/SHB/SPHK1/SULF1/TGFB2/TGFBI/THBS1/TNFRSF12A/UNC5B |
| Epithelial cell differentiation | 47 | ACADVL/ACTA2/AFDN/AJAP1/AKR1C3/ARHGEF26/B4GALT1/CCND1/CDKN1A/CLDN1/COL4A1/CYP26B1/DSC2/DSG2/ELF3/EPHA2/ERBB4/EZR/HEG1/HES1/HIF1A/ICAM1/IVL/JUP/KRT13/KRT18/KRT33B/KRT7/KRT80/KRT86/LBH/LIF/MAF/MYO7A/NRG1/PALLD/PAX6/PODXL/RARA/SERPINE1/SFRP4/SIPA1L3/SRC/TGM1/TP63/TPRN/TRIOBP |
| Positive regulation of cell migration | 42 | ANXA3/BDKRB1/CLDN1/CSF1R/CTSH/CXCL8/DOCK5/EDN2/EMC10/ENPP2/FAM83H/FOXP1/GPER1/HDAC7/HIF1A/ICAM1/IGF1R/IGFBP5/ITGA5/ITGAV/MCAM/MYO1C/NEDD9/NOX4/P2RY6/PDGFD/PIK3R1/PLK2/PODXL/RAC2/RHOB/SEMA3B/SEMA7A/SERPINE1/SH3RF2/SPHK1/SRC/SSH1/TGFB2/THBS1/VSIR/ZNF268 |
| Regulation of vasculature development | 31 | ANGPTL4/ANXA3/BMPER/COL4A2/COL4A3/CTSH/CXCL8/EFNB2/EMC10/EMP2/ENPP2/EPHA2/GPER1/HDAC7/HIF1A/ITGA5/JUP/MYOCD/NPPB/PDGFD/PLK2/PLXND1/PTGIS/RHOB/SERPINE1/SFRP1/SPHK1/SULF1/TGFB2/THBS1/TNFRSF12A |
| Epidermis development | 30 | AKR1C3/CCN2/CYP26B1/DSC2/DSG2/EPHA2/FOXQ1/HES1/IGFBP5/IVL/JUP/KRT13/KRT18/KRT33B/KRT7/KRT80/KRT86/LAMB3/LGR4/MYO7A/PALLD/PAX6/PLOD1/SFRP4/TGFB2/TGM1/TNFRSF19/TP63/TPRN/TRIOBP |
| Positive regulation of cell motility | 42 | ANXA3/BDKRB1/CLDN1/CSF1R/CTSH/CXCL8/DOCK5/EDN2/EMC10/ENPP2/FAM83H/FOXP1/GPER1/HDAC7/HIF1A/ICAM1/IGF1R/IGFBP5/ITGA5/ITGAV/MCAM/MYO1C/NEDD9/NOX4/P2RY6/PDGFD/PIK3R1/PLK2/PODXL/RAC2/RHOB/SEMA3B/SEMA7A/SERPINE1/SH3RF2/SPHK1/SRC/SSH1/TGFB2/THBS1/VSIR/ZNF268 |
| Extracellular matrix organization | 34 | ADAMTS2/ADAMTS5/ADAMTS7/ADTRP/B4GALT1/CCN2/COL4A1/COL4A2/COL4A3/COL5A1/COL9A2/DDR1/ELF3/FLRT2/ICAM1/ITGA5/ITGA7/ITGAV/ITGB5/LAMB3/LOX/LOXL2/LTBP3/MELTF/MMP2/MMP24/PHLDB1/RIC1/SERPINE1/SULF1/SULF2/TGFB2/TGFBI/THBS1 |
| Extracellular structure organization | 34 | ADAMTS2/ADAMTS5/ADAMTS7/ADTRP/B4GALT1/CCN2/COL4A1/COL4A2/COL4A3/COL5A1/COL9A2/DDR1/ELF3/FLRT2/ICAM1/ITGA5/ITGA7/ITGAV/ITGB5/LAMB3/LOX/LOXL2/LTBP3/MELTF/MMP2/MMP24/PHLDB1/RIC1/SERPINE1/SULF1/SULF2/TGFB2/TGFBI/THBS1 |
| Cell junction assembly | 36 | ACTN1/AFDN/AMIGO2/ARVCF/ASIC2/BDNF/CDH10/CDH11/CLDN1/CLSTN2/CORO1C/EFNB2/EPHA2/ERBB4/FLRT2/FLRT3/FMN1/GPC4/HDAC7/HEG1/ITGA5/JUP/LAMB3/LIMCH1/LSR/MYO1C/NLGN4X/NRG1/OXTR/PLXND1/PTPRJ/SFRP1/SRC/THBS1/TNS1/UGT8 |