Table 2.
Gene Set Enrichment Analysis was performed on differentially expressed transcripts in ARPE-19 cells with modified EMP2 levels, with the top 10 Go ontology terms from Group 2 (EMP2 < WT < KD) shown.
| Description | Count | Genes |
|---|---|---|
| Response to wounding | 44 | ABHD2/ANO6/ANXA6/APOE/CAV1/CD109/CD36/CSRP1/DOCK8/DPYSL3/ETS1/F2R/F2RL2/F3/FBLN1/GAS6/GLI3/GNA12/ITGB1/ITPK1/KCNK2/MDK/MYLK/MYOF/NREP/NRP1/PLAT/PLAU/PPARD/PRCP/PRKAR2B/PTPRF/PTPRS/RAB27A/SDC1/SERPINA1/SH2B3/TFPI/TGFBR2/TIMP1/TLR4/TNFAIP3/VANGL2/WNT5B |
| Blood vessel morphogenesis | 42 | ADGRA2/ANGPTL2/APOE/ATP2B4/C3/CAV1/CCBE1/COL8A2/CREB3L1/CYP1B1/ECM1/EGFL7/EPAS1/ETS1/F3/FGFR1/FMNL3/FZD8/GPNMB/HMGA2/ITGB1/LDLR/LEF1/LRP5/MDK/MMP14/MMP19/MYLK/NRP1/PRCP/PRRX1/PTPRB/ROBO4/SERPINF1/SHC1/SMO/SPRY2/ STAT3/TGFBR2/TIE1/TNFAIP3/ZMIZ1 |
| Positive regulation of cellular component movement | 41 | ADGRA2/ANO6/ARHGEF2/CAV1/CCBE1/CCL7/CD274/CEMIP/CMKLR1/CSF1/DAB2/DOCK8/ETS1/F2R/F3/FGFR1/GAS6/GPNMB/IL1R1/ITGA6/ITGB1/LAMB1/LEF1/LPAR1/MAP2/MDK/MMP14/MMP9/MYLK/NRP1/PLAU/PREX1/SEMA3F/SEMA6B/SMO/SOD2/SPRY2/STAT3/ STMN1/TGFBR2/WNT5B |
| Inflammatory response | 42 | ANO6/APOE/C3/C4B/CAMK4/CCL7/CD36/CLU/CMKLR1/CSF1/ECM1/ETS1/F2R/F3/HRH1/IFI16/IL1R1/IL1RAP/IL4R/IRAK2/LDLR/MAPT/MDK/MGLL/MMP9/MVK/NAMPT/OSMR/PPARD/PRCP/PTX3/PXK/S1PR3/SDC1/SERPINA1/SERPINF1/SMO/STAT3/TIMP1/TLR4/TNFAIP3/TNFRSF11A |
| Secondary alcohol metabolic process | 21 | ABCA1/ACAT2/APOE/DGAT2/DHCR7/ELOVL6/FDFT1/FDPS/FGFR1/IDI1/LDLR/LRP5/LSS/MSMO1/MVD/MVK/NPC1/PPARD/SCD/SQLE/ SREBF2 |
| Positive regulation of cell migration | 39 | ADGRA2/ANO6/ARHGEF2/CAV1/CCBE1/CCL7/CD274/CEMIP/CMKLR1/CSF1/DAB2/DOCK8/ETS1/F2R/F3/FGFR1/GAS6/GPNMB/IL1R1/ITGA6/ITGB1/LAMB1/LEF1/LPAR1/MDK/MMP14/MMP9/MYLK/NRP1/PLAU/PREX1/SEMA3F/SEMA6B/SMO/SOD2/SPRY2/STAT3/TGFBR2/WNT5B |
| Cholesterol metabolic process | 20 | ABCA1/ACAT2/APOE/DGAT2/DHCR7/ELOVL6/FDFT1/FDPS/IDI1/LDLR/LRP5/LSS/MSMO1/MVD/MVK/NPC1/PPARD/SCD/SQLE/SREBF2 |
| Sterol metabolic process | 21 | ABCA1/ACAT2/APOE/CYP1B1/DGAT2/DHCR7/ELOVL6/FDFT1/FDPS/IDI1/LDLR/LRP5/LSS/MSMO1/MVD/MVK/NPC1/PPARD/SCD/SQLE/ SREBF2 |
| Wound healing | 36 | ANO6/ANXA6/APOE/CAV1/CD109/CD36/CSRP1/DOCK8/ETS1/F2R/F2RL2/F3/FBLN1/GAS6/GLI3/GNA12/ITGB1/ITPK1/MYLK/MYOF/PLAT/PLAU/PPARD/PRCP/PRKAR2B/RAB27A/SDC1/SERPINA1/SH2B3/ TFPI/TGFBR2/TIMP1/TLR4/TNFAIP3/VANGL2/WNT5B |
| Positive regulation of cell motility | 39 | ADGRA2/ANO6/ARHGEF2/CAV1/CCBE1/CCL7/CD274/CEMIP/CMKLR1/CSF1/DAB2/DOCK8/ETS1/F2R/F3/FGFR1/GAS6/GPNMB/IL1R1/ITGA6/ITGB1/LAMB1/LEF1/LPAR1/MDK/MMP14/MMP9/MYLK/NRP1/PLAU/PREX1/SEMA3F/SEMA6B/SMO/SOD2/SPRY2/STAT3/TGFBR2/WNT5B |