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. 2022 Nov 12;13:6881. doi: 10.1038/s41467-022-34660-4

Fig. 8. Pou2f3 deficiency abolishes thymic involution-mediated T cell aging during schistosome infection.

Fig. 8

a–c Representative morphology and quantified weight and cellularity of thymus from WT or Pou2f3−/− mice 8 weeks after schistosome infection (n = 6 mice, pool of two independent experiments). Infected WT versus Uninfected WT, P < 0.0001 (weight), P < 0.0001 (cells); Infected WT versus Infected Pou2f3−/−, P = 0.0112 (weight), P = 0.0031 (cells); One-way ANOVA with Tukey’s multiple comparisons. d, e Representative and quantified flow cytometry of CFSE MFI of CFSE-labeled naive CD4+ T cells from uninfected or infected WT or Pou2f3−/− mice stimulated with anti-CD3 and anti-CD28 antibodies (n = 6 mice, pool of two independent experiments). Infected WT versus Uninfected WT, P < 0.0001; Infected WT versus Infected Pou2f3−/−, P < 0.0001; One-way ANOVA with Tukey’s multiple comparisons. f Representative image of histology of liver from WT or Pou2f3−/− mice after schistosome infection; Scale bar, 100 μm. g The areas of granulomas around a single egg (n = 6 mice, pool of two independent experiments), P < 0.0001, Unpaired two-tailed Student’s t-test. All data are shown as the mean ± s.d. **P < 0.01, ***P < 0.001. Source data are provided as a Source Data file.