Table 2.
Overall structural differences for the directed group contrasts, reporting results both with cFWE and TFCE cluster correction including peak voxel MNI-coordinates and cluster sizes.
| Cluster | Region | MNI | Cluster size (voxels) |
n (experiments contributed to cluster) |
cFWE | TFCE | References (experiments contributed to cluster) |
||
|---|---|---|---|---|---|---|---|---|---|
| x | y | z | |||||||
| MAIN ANALYSIS | |||||||||
| Healthy controls > patients with chronic pain | |||||||||
| Cluster 1 | r insula lobe | 38 | 14 | 0 | 372 | 25 | * | Baliki et al.[10], Baliki et al.[10], Boehme et al.[14], Fritz et al.[29], Geha et al.[30], Gustin et al.[36], Ikeda et al.[41], Lai et al.[53], Lai et al.[53], Luchtmann et al.[62], Messina et al.[71], Nair et al.[79], Niddam et al.[83], Obermann et al.[78], Petrusic et al.[87], Pomares et al.[91], Riederer et al.[95], Rodriguez-Raecke et al.[97], Schmidt-Wilcke et al.[102], Seminowicz et al.[107], Seminowicz et al.[109], Valet et al.[124], Yoon et al.[136], Younger et al.[137], Zhang et al.[140] | |
| r IFG (p. orbitalis) | 36 | 30 | −18 | * | |||||
| r insula lobe | 30 | 22 | −10 | * | |||||
| r IFG (p. orbitalis) | 44 | 12 | 4 | * | |||||
| r insula lobe | 42 | 4 | 6 | * | |||||
| r insula lobe | 34 | 12 | −16 | * | |||||
| Cluster 2 | l ACC | −6 | 36 | 12 | 339 | 25 | * | Absinta et al.[2], Agostini et al.[3], Barad et al.[11], Hubbard et al.[40], Jensen et al.[43], Luchtmann et al.[62], Mordasini et al.[74], Nair et al.[79], Nan et al.[80], Obermann et al.[78], Pomares et al.[91], Riederer et al.[95], Rocca et al.[96], Rodriguez-Raecke et al.[97], Ruscheweyh et al.[99], Schmidt-Wilcke et al.[102], Schmidt-Wilcke et al.[100], Seminowicz et al.[109], Sinding et al.[113], Valet et al.[124], Wang et al.[127], Wu et al.[131], Wu et al.[131], Yu et al.[138] | |
| l ACC | −2 | 38 | 4 | * | |||||
| l ACC | −4 | 26 | 30 | * | |||||
| r ACC | 12 | 34 | 28 | * | |||||
| l superior medial gyrus | 0 | 40 | 28 | * | |||||
| r ACC | 6 | 34 | 28 | * | |||||
| Cluster 3 | l insula lobe | −38 | 18 | 0 | 137 | 17 | * | Absinta et al.[2], Baliki et al.[10], Boehme et al.[14], Gustin et al.[36], Kuchinad et al.[47], Lai et al.[52], Naegel et al.[78], Nair et al.[79], Nair et al.[79], Niddam et al.[83], Obermann et al.[78], Riederer et al.[95], Rodriguez-Raecke et al.[97], Schmidt-Wilcke et al.[102], Seminowicz et al.[109], Wang et al.[128], Yoon et al.[136] | |
| l insula lobe | −32 | 14 | −12 | * | |||||
| l insula lobe | −34 | 16 | −10 | * | |||||
| l insula lobe | −30 | 22 | 2 | * | |||||
| Patients with chronic pain > healthy controls | |||||||||
| No suprathreshold cluster | |||||||||
Notes. cFWE = Family-wise error correction ; TFCE = Threshold Free Cluster Enhancement; MNI = Montreal Neurological Institute stereotaxic space; l = left; r = right; IFG = inferior frontal gyrus; ACC = anterior cingulate cortex.