Table 4.
Gray matter differences for the directed group contrasts, reporting results both with cFWE and TFCE cluster correction including peak voxel MNI-coordinates and cluster sizes.
| Cluster | Region | MNI | Cluster size (voxels) |
n (experiments contributed to cluster) |
cFWE | TFCE | References (experiments contributed to cluster) |
||
|---|---|---|---|---|---|---|---|---|---|
| x | y | z | |||||||
| GRAY MATTER | |||||||||
| Healthy controls > patients with chronic pain | |||||||||
| Cluster 1 | l ACC | −4 | 26 | 30 | 144 | 13 | * | Absinta et al.[2], Agostini et al.[3], Mordasini et al.[74], Nan et al.[80], Obermann et al.[78], Pomares et al.[91], Riederer et al.[95], Rocca et al.[96], Rodriguez-Raecke et al.[97], Ruscheweyh et al.[99], Schmidt-Wilcke et al.[102], Schmidt-Wilcke et al.[100], Valet et al.[124] | |
| r ACC | 12 | 34 | 28 | * | |||||
| l superior medial gyrus | 0 | 40 | 28 | * | |||||
| r ACC | 6 | 34 | 28 | * | |||||
| l ACC | −4 | 40 | 16 | * | |||||
| l ACC | −6 | 40 | 22 | * | |||||
| Cluster 2 | r insula lobe | 30 | 20 | −10 | 116 | 14 | * | Baliki et al[10], Boehme et al.[14], Geha et al.[30], Gustin et al.[36], Ikeda et al.[41], Luchtmann et al.[62], Muthulingam et al.[77], Niddam et al. [83], Obermann et al.[78], Rodriguez-Raecke et al.[97], Schmidt-Wilcke et al.[102], Seminowicz et al.[107], Valet et al.[124], Yoon et al.[136] | |
| r insula lobe | 34 | 12 | −16 | * | |||||
| Cluster 3 | r insula lobe | 44 | 2 | 6 | 62 | 12 | * | Absinta et al.[2], Baliki et al.[10], Baliki et al.[10], Boehme et al.[14], Fritz et al.[29], Ivo et al.[42], Pomares et al.[91], Riederer et al.[95], Rodriguez-Raecke et al.[97], Schmidt-Wilcke et al.[102], Valet et al.[124], Younger et al.[137] | |
| r IFG (p. opercularis) | 46 | 12 | 4 | * | |||||
| r insula lobe | 40 | 14 | −2 | * | |||||
| Cluster 4 | l insula lobe | −38 | 18 | 0 | 26 | 11 | * | Absinta et al.[2], Baliki et al.[10], Boehme et al.[14], Gustin et al.[36], Kuchinad et al.[47], Niddam et al.[83], Riederer et al.[95], Rodriguez-Raecke et al.[97], Schmidt-Wilcke et al.[102], Wang et al.[127], Yoon et al.[136] | |
| Cluster 5 | l superior medial gyrus | −4 | 62 | 12 | 20 | 10 | * | Ceko et al.[19], Fritz et al.[29], Kuchinad et al.[47], Lai et al.[53], Pomares et al.[91], Rodriguez-Raecke et al.[97], Seminowicz et al.[107], Valet et al.[124] | |
| Patients with chronic pain > healthy controls | |||||||||
| No suprathreshold cluster | |||||||||
Notes. cFWE = Family-wise error correction ; TFCE = Threshold Free Cluster Enhancement; MNI = Montreal Neurological Institute stereotaxic space; l = left; r = right; IFG = inferior frontal gyrus; ACC = anterior cingulate cortex.