Table 2:

Coefficients are estimates of the differences in primary and secondary outcome measures over 4 years between participants with sustained synovitis (exposure), defined by two different definitions, and participants without sustained synovitis (non-exposure cohort) (n=161 for Definition (i) with 80 exposed and n=179 for Definition (ii) with 132 non-exposure group) and their corresponding P values and 95% confidence intervals for WORMS parameters.

Definition 1: ACLOAS+MOAKS
Change in WORMS scores between baseline and 4-year follow-up
Primary outcomes
Outcomes measures	Beta coefficients	P	95% Conf. Interval
Patellar cartilage	0.29	0.035	0.02 0.56
Med. femoral cartilage	0.05	0.639	−0.16 0.26
Med. tibial cartilage	0.29	0.005	0.08 0.50
Lat. femoral cartilage	−0.02	0.794	−0.22 0.17
Lat. tibial cartilage	0.16	0.097	−0.03 0.36
Cartilage max	0.15	0.324	−0.15 0.46
Secondary outcomes
Med. meniscus max	0.18	0.220	−0.11 0.48
Lat. meniscus max	−0.03	0.728	−0.20 0.14
BMEP max	0.24	0.091	−0.04 0.53
Ligament max	0.13	0.019	0.02 0.24
Definition 2: ACLOAS+MOAKS+SPS
Change in WORMS scores between baseline and 4-year follow-up
Primary outcomes
Patellar cartilage	0.36	0.017	0.06 0.65
Med. femoral cartilage	0.30	0.046	0.005 0.61
Med. tibial cartilage	0.24	0.095	−0.04 0.54
Lat. femoral cartilage	0.11	0.166	−0.04 0.27
Lat. tibial cartilage	0.31	0.093	−0.05 0.68
Cartilage max	0.31	0.077	−0.03 0.66
Secondary outcomes
Med. meniscus max	0.18	0.294	−0.15 0.52
Lat. meniscus max	0.003	0.974	−0.19 0.20
BMEP max	0.29	0.074	−0.02 0.61
Ligament max	0.07	0.368	−0.08 0.22

Abbreviations: BMEP (bone marrow edema pattern); ACLOAS (Anterior Cruciate Ligament OsteoArthritis Score); MOAKS (MRI Osteoarthritis Knee Score); SPS knee (synovial proliferation score in knee); max (maximum score); Med (medial); Lat (lateral); Significant findings are displayed in bold.