Table 3:
Coefficients of the differences in primary and secondary outcome measures over 4 years between exposure and non-exposure groups as a function of gender and their corresponding P values and 95% confidence intervals.
| Definition 1: ACLOAS+MOAKS | ||||||
| Change in WORMS scores between baseline and 4-year follow-up | ||||||
| Primary outcomes | ||||||
| Men | Women | |||||
| Beta coefficient | P value | 95% Confidence interval | Beta coefficient | P value | 95% Confidence interval | |
| Patellar cartilage | 0.05 | 0.818 | −0.40 0.50 | 0.48 | 0.006 | 0.14 0.83 |
| Med. femoral cartilage | −0.08 | 0.561 | −0.39 0.21 | 0.17 | 0.295 | −0.15 0.49 |
| Med. tibial cartilage | 0.21 | 0.209 | −0.12 0.56 | 0.43 | 0.001 | 0.18 0.68 |
| Lat. femoral cartilage | −0.21 | 0.288 | −0.61 0.18 | 0.10 | 0.177 | −0.04 0.25 |
| Lat. tibial cartilage | −0.02 | 0.877 | −0.34 0.29 | 0.33 | 0.010 | 0.08 0.58 |
| Cartilage max | −0.32 | 0.229 | −0.85 0.20 | 0.50 | 0.009 | 0.13 0.88 |
| Secondary outcomes | ||||||
| Med. meniscus max | −0.07 | 0.783 | −0.64 0.48 | 0.39 | 0.010 | 0.09 0.69 |
| Lat. meniscus max | −0.08 | 0.551 | −0.35 0.18 | 0.02 | 0.835 | −0.22 0.28 |
| BMEP max | 0.05 | 0.769 | −0.32 0.43 | 0.49 | 0.029 | 0.05 0.93 |
| Ligament max | 0.03 | 0.595 | −0.09 0.15 | 0.20 | 0.038 | 0.01 0.39 |
| Definition 2: ACLOAS+MOAKS+SPS | ||||||
| Change in WORMS scores between baseline and 4-year follow-up | ||||||
| Primary outcomes | ||||||
| Patellar cartilage | 0.23 | 0.421 | −0.33 0.79 | 0.39 | 0.029 | 0.04 0.74 |
| Med. femoral cartilage | 0.29 | 0.222 | −0.17 0.76 | 0.34 | 0.112 | −0.08 0.77 |
| Med. tibial cartilage | 0.12 | 0.583 | −0.32 0.57 | 0.35 | 0.089 | −0.05 0.76 |
| Lat. femoral cartilage | 0.05 | 0.822 | −0.47 0.59 | 0.10 | 0.159 | −0.04 0.24 |
| Lat. tibial cartilage | 0.11 | 0.579 | −0.28 0.51 | 0.13 | 0.260 | −0.10 0.38 |
| Cartilage max | 0.09 | 0.765 | −0.56 0.76 | 0.32 | 0.120 | −0.08 0.74 |
| Secondary outcomes | ||||||
| Med. meniscus max | −0.22 | 0.482 | −0.87 0.41 | 0.35 | 0.083 | −0.04 0.76 |
| Lat. meniscus max | −0.02 | 0.877 | −0.35 0.30 | 0.02 | 0.877 | −0.24 0.28 |
| BMEP max | 0.09 | 0.717 | −0.40 0.59 | 0.40 | 0.076 | −0.04 0.84 |
| Ligament max | −0.02 | 0.830 | −0.30 0.24 | 0.08 | 0.420 | −0.12 0.28 |
Abbreviations: BMEP (bone marrow edema pattern); ACLOAS (Anterior Cruciate Ligament OsteoArthritis Score); MOAKS (MRI Osteoarthritis Knee Score); HS (Hoffa synovitis); SPS knee (synovial proliferation score in knee); max (maximum score); Med (medial); Lat (lateral); Significant findings are displayed in bold.