Table 3.
The KEGG pathways of down-regulated proteins during conversion of L. tropica metacyclic into the amastigote-like
| Pathway ID | Pathway description | Gene NO | FDR | Matching proteins (IDs) |
|---|---|---|---|---|
| 3010 | Ribosome | 11 | 4.13E–10 | LmjF.07.0510, LmjF.13.1230, LmjF.15.0200, LmjF.15.1207, LmjF.16.0460, LmjF.24.0040, LmjF.32.0450,LmjF.35.0420,LmjF.35.3800,LmjF.36.0990,LmjF.36.2870 |
| 1200 | Carbon metabolism | 9 | 1.76E–08 | LmjF.12.0530, LmjF.14.1160, LmjF.24.1630, LmjF.27.1810, LmjF.29.1960, LmjF.29.2510, LmjF.32.3310,LmjF.36.2660,LmjF.36.6650 |
| 10 | Glycolysis/gluconeogenesis | 7 | 2.19E–08 | LmjF.12.0530, LmjF.14.1160, LmjF.27.1810, LmjF.29.2510, LmjF.32.3310, LmjF.36.2660, LmjF.36.6650 |
| 1110 | Biosynthesis of secondary metabolites | 11 | 2.19E–08 | LmjF.12.0530, LmjF.14.1160, LmjF.17.0725, LmjF.24.1630, LmjF.25.1770, LmjF.27.1810, LmjF.29.1960,LmjF.29.2510,LmjF.32.3310,LmjF.36.2660,LmjF.36.6650 |
| 1100 | Metabolic pathways | 14 | 2.51E–07 | LmjF.12.0530, LmjF.14.1160, LmjF.15.1040, LmjF.17.0725, LmjF.24.1630, LmjF.25.1770, LmjF.27.1810, LmjF.29.1960, LmjF.29.2510, LmjF.32.3310, LmjF.34.3670, LmjF.36.2660, LmjF.36.3910,LmjF.36.6650 |
| 20 | Citrate cycle (TCA cycle) | 5 | 6.25E–06 | LmjF.24.1630,LmjF.27.1810,LmjF.29.1960,LmjF.32.3310,LmjF.36.2660 |
| 620 | Pyruvate metabolism | 4 | 0.000217 | LmjF.27.1810,LmjF.29.1960,LmjF.32.3310,LmjF.36.2660 |
| 190 | Oxidative phosphorylation | 3 | 0.0185 | LmjF.24.1630,LmjF.31.1220,LmjF.34.3670 |
| 1230 | Biosynthesis of amino acids | 3 | 0.037 | LmjF.14.1160,LmjF.29.2510,LmjF.36.6650 |
| 30 | Pentose phosphate pathway | 2 | 0.0395 | LmjF.12.0530,LmjF.29.2510 |
| 260 | Glycine, serine and threonine metabolism | 2 | 0.0395 | LmjF.32.3310,LmjF.36.6650 |
FDR false discovery rate