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. 2022 Nov 5;11(21):3508. doi: 10.3390/cells11213508

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The potential ferroptosis-related pathways in annulus fibrosus cells (left) and endplate chondrocytes (right). DMT1, divalent metal transporter 1; FTH1, ferritin heavy chain 1; FPN, ferroportin; GPX4, glutathione peroxidase 4; GSH, glutathione; IL-6, interleukin-6; IL-6R, interleukin-6 receptor; LC3, microtubule-associated protein light chain 3; NCOA4, nuclear receptor coactivator 4; ROS, reactive oxygen species; SLC7A11, cystine/glutamate antiporter; TBHP, tert-butyl hydroperoxide; TfR1, transferrin receptor 1.