Table 1.

Ferroptosis in intervertebral disc cells.

Cell type	Sample	Upstream Regulator	Target	Effect	Reference
Nucleus pulposus cell	Male Sprague–Dawley rats	DNMTs	Downregulating GPX4	Inducing ferroptosis	[88]
	Sprague–Dawley rats	NCOA4	Consuming FTH1	Inducing ferroptosis	[19]
	Human	JNK/MTF1	Downregulating FPN	Inducing ferroptosis	[69]
	Human and male Sprague–Dawley rats	FTL and HO-1	Iron overload	Inducing ferroptosis	[13]
	Human	Heme catabolism	Consuming GPX4	Inducing ferroptosis	[74]
	C57BL/6 male mice	circ_0072464/miR-431	Upregulating NRF2	Inhibiting ferroptosis	[14]
	Human	miR-874-3p/ATF3	Downregulating SLC7A11	Inducing ferroptosis	[94]
Annulus fibrosus cell	Sprague–Dawley rats	NCOA4	Consuming FTH1	Inducing ferroptosis	[19]
Endplate chondrocyte	Human	miR-10a-5p	IL-6 receptor	Inhibiting ferroptosis	[7]
	C57BL/6 male mice	Ferric ammonium citrate	Accumulating ROS	Inducing ferroptosis	[15]