Table 1.
Comparison between the SGLT2 inhibitors affinity and pleotropic effects.
| Sotagliflozin | Canagliflozin | Dapagliflozin | Empagliflozin | Ertugliflozin | |
|---|---|---|---|---|---|
| Affinity for SGLT2 over SGLT1 | 20 fold [14] | 250 fold [14] (Dual inhibitor) |
1200 fold [14] | 2500 fold [14] | 2500 fold [14] |
| AChE inhibition | Ki 5.6 µM [15] | Ki 0.13 µM (most potent) [15] |
Ki 25.02 µM [15] | Ki 0.177 µM [15] | Ki 31.69 µM [15] |
| Anti-inflammatory | Not applicable | Yes [16] | Yes [17] | Yes [18] | No [19] |
| Oxidative stress inhibition | Yes [20] | Yes [21] | Yes [22] | Yes [23] | Yes [24] |
| Nervous system remodeling | Not applicable | Not applicable | Not applicable | Yes [25] | Not applicable |
| mTOR signaling reduction | Not applicable | Yes [26] | Yes [26] | Yes [27] | Yes [28] |