Table 10.

The metal complexes derived from HL with COX2 [PDB code: 5IKT] observed interaction parameters.

Compound	Sites of Ligand	Receptor Sites	Interaction Kind	Bond Distance (Å)	Binding Energy (kcal/mol)	The Energy of Total Free Binding (kcal/mol)
HL	O(1)	HIS 388	H-donor	2.87	−1	−7.52
	C(12)	HIS 386	H-pi	4.34	−0.8
Co-L	N(11)	HIS 214	H-acceptor	2.97	−1.12	−9.41
Cu-L	O(1)	HIS 388	H-donor	2.97	−4.6	−8.09
	Ph	HIS 386	H-pi	4.39	−1.6
Ni-L	Ph	HIS 214	H-pi	3.55	−0.8	−9.51
	Ph	HIS 386	H-pi	4.19	−0.6
Gd-L	N(10)	HIS 214	H-acceptor	3.18	−2.3	−8.05
	Ph	LYS 211	H-pi	4.15	−1
	Ph	HIS 386	pi-pi	3.94	0
Sm-L	Ph	HIS 386	H-pi	4.28	−0.8	−10.04
	Ph	HIS 217	H-pi	3.79	−0.6
	Ph	GLN 203	H-pi	4.47	−0.6