Table 11.

Predicted physicochemical descriptors of ibuprofen drug, the synthesized compounds HL, and its cobalt complexes.

Compound	Molecular Weight (g/mol)	Heavy Atoms	Rotatable Bonds	H-Bond Donors	H-Bond Acceptors	Fraction Csp3	Solubility LogS (Silicos-IT) (Water)	XLogP3	WLOGP	Molar Refractivity	TPSA (Å2)	GI Absorption	BBB Permeant	P-gp substrate	Log Kp (cm/s)
Ibuprofen	206.28	15	4	1	2	0.46	−3.44	3.50	3.07	62.18	37.30	High	Yes	No	−5.07
HL	324.42	24	7	2	3	0.30	−6.07	5.47	3.84	98.41	61.69	High	Yes	No	−4.40
L-Co	723.77	50	8	1	7	0.35	−11.8	11.17	7.29	203.71	77.35	High	No	Yes	−2.78