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In vitro COX-1 and COX-2 inhibition of HI and HL.
| Compound | IC50 (µM) a | ||
|---|---|---|---|
| COX-1 | COX-2 | COX-2 SI b | |
| HI | 7.5 | 4.3 | 1.7 |
| HL | 8.6 | 4.9 | 1.8 |
| Ibuprofen | 12.9 | 31.4 | 0.4 |
| Indomethacin | 0.4 | 0.1 | 5.0 |
| Diclofenac sodium | 3.8 | 0.8 | 4.5 |
a IC50 value represents the compound concentration that is required to produce 50% inhibition of COX-1 or COX-2 which is the mean value of three determinations where the deviation from the mean is <10% of the mean value. b Selectivity index (COX-1 IC50/COX-2 IC50).
