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(A) AuNPs in imaging and gene-silencing NP design. The siRNA payload is released when the nanoparticle is hydrolyzed at a low pH. (B) Three-dimensional optical coherence tomography pictures of AuNP-based nanoparticles (the lower intensity image on the right confirms NPs’ disintegration at lower pH). (C) When eGFP-expressing NIH 3T3 cells are treated with AuNPs–siRNA at low pH, fluorescence microscopy demonstrates gene silencing (reprinted with permission from [103]).
