Table 1.
Baseline characteristics of all ICI patients and healthy subjects (n = 64).
| Subjects Characteristics |
Responders (R; n = 28) |
Non-Responders (NR; n = 36) |
p Value (R~NR) |
Controls (C; n = 10) |
p Value (C~R + NR) |
|---|---|---|---|---|---|
| Sex, n (%) | 0.2 a | 0.732 a | |||
| Male | 15 (54) | 25 (69) | 5 (50) | ||
| Female | 13 (46) | 11 (31) | 5 (50) | ||
| Age (years), | 0.2 b | 0.0193 b | |||
| median (range) | 64 (41–84) | 69 (32–92) | 52.5 (36–67) | ||
| M-stage at diagnosis c, n (%) | 0.3 a | NA | NA | ||
| IV M1a | 7 (25) | 9 (23) | |||
| IV M1b | 5 (18) | 5 (14) | |||
| IV M1c | 9 (32) | 13 (36) | |||
| IV M1d | 4 (14) | 9 (25) | |||
| IIIc | 3 (11) | 0 (0) | |||
| Serum LDH, n (%) | 0.1 a | NA | NA | ||
| Normal | |||||
| (≤250 U/L) | 22 (79) | 21 (58) | |||
| Elevated | |||||
| (>250 U/L) | 6 (21) | 15 (42) | |||
| Serum LDH, | 0.04 b | NA | NA | ||
| median (range) | 197.5 (121–474) | 238 (141–1173) |
LDH, lactate dehydrogenase. a Fisher’s exact test. b Kruskal–Wallis test. c American Joint Committee on Cancer (AJCC) 8th edition.