Figure 2.

Important targets for osteosarcoma therapy and their main functions. Various receptors capable of acting as targets in OS cells serve different purposes. PDGFR promotes the survival and migration of OS cells, IGF-1 receptor promotes their differentiation; these two receptors can work together to produce mTOR in the PI3K pathway to enable OS cells to proliferate and metastasize. In addition to its vasculogenic role, VEGFR activates MEK, which has the effect of promoting OS gene expression. In addition to its angiogenic effects, VEGFR activates MEK, which also makes a useful contribution in promoting OS gene expression. Targets that also have important roles in the cell cycle, such as WEE1 acting at the G2/M test site, AURKA/B acting in mitosis, and CDKs produced in the G1 phase, show facilitative effects on OS.