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. 2022 Nov 2;14(21):5396. doi: 10.3390/cancers14215396

Figure 1.

Figure 1

Differential enrichment of modified histone proteins on the KSHV genome during hypoxic reactivation. (A) The histogram for differential enrichment of AcH3 on the KSHV genome in normoxic and hypoxic conditions. (B) The histogram for differential enrichment of H3K4Me3 on the KSHV genome in normoxic and hypoxic conditions. (C) The histogram for differential enrichment of H3K9Me3 on the KSHV genome in normoxic and hypoxic conditions. (D) The histogram for differential enrichment of H3K27Me3 on the KSHV genome in normoxic and hypoxic conditions. A complete list of statistically significant enrichment region on the KSHV genome is provided as Supplementary File S1. (E) Validation of ChIP sequencing result using ChIP-qPCR. ChIP DNA was used to perform real-time PCR using primers specific to ORF6, ORFK6, ORF12, ORF26, ORF29, ORF34/36, ORF61, and ORF73 (N = Normoxia, H = Hypoxia). The p value of <0.05 was considered statistically significant. * p value < 0.05; ** p value < 0.01; *** p value < 0.005.