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. 2022 Nov 2;14(21):5396. doi: 10.3390/cancers14215396

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Identification of preferential regions of the KSHV genome for initiation of replication under hypoxic conditions. (A–C) Differential enrichment of LANA, RTA, and DNA Polymerase 1α on the KSHV genome in normoxic and hypoxic conditions. A complete list of statistically significant enrichment regions on the KSHV genome is provided as Supplementary File S1. (D) Single Molecule analysis of replicated DNA for identification of regions of nucleotide incorporation within the KSHV genome. Representative images for single molecule analysis of replicated DNA are shown for cells grown under hypoxic conditions. Blue fluorescence represents KSHV-specific probes; red represents the incorporation of IdU, while green represents CldU incorporation. Arrows represents areas of incorporation of the second pulsed nucleotide analog (N = Normoxia, H = Hypoxia).