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. 2022 Oct 23;14(21):5196. doi: 10.3390/cancers14215196

Figure 4.

Figure 4

NcRNA-encoded peptides/proteins regulated protein stability. (a) FBXW7-185aa competitively interacted with USP28 to release FBXW7α and facilitated c-Myc degradation, inhibiting proliferation and metastasis in TNBC or inhibiting proliferation in GBM; EIF6-224 aa interacted with MYH9 to prohibited MYH9 degradation, promoting proliferation and metastasis in TNBC; SHPRH-146aa protected SHPRH from ubiquitination and induced PCNA degradation, promoting proliferation in GBM; circMAPK14-175aa competitively bound to MKK6 to repress p-MAPK14 and facilitated FOXC1 degradation, inhibiting proliferation and metastasis in CRC; circPLCE1-411 interacted with HSP90α/RPS3 to induce RPS3 dissociation, RPS3 interacted with HSP70-CHIP to induce RPS3 degradation, inhibiting proliferation and metastasis in CRC. (b) rtEGFR interacted with EGFR to reduce EGFR endocytosis and decrease EGFR ubiquitination in lysosomes, promoting proliferation in GBM.