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. 2022 Nov 3;23(21):13482. doi: 10.3390/ijms232113482

Figure 2.

Figure 2

miR-221 and miR-222 are involved in skeletal muscle regeneration. (A) Venn diagram showing co-expression of miRNAs 1 day and 3 days after CTX injection (GSE141879). (B) Co-upregulated (red) and co-downregulated (blue) miRNAs. (C) Binding sites of co-upregulated miRNAs to the 3′UTR of ESR1. (D) Expression of ESR1 during mouse skeletal muscle regeneration. (E) Expression of miR-142-5p (E1), miR-15b (E2), miR-200c (E3), miR-223 (E4), miR-221 (E5) and miR-222 (E6) during skeletal muscle regeneration in the GEO database (GSE37479, GSM920825 (day1), GSM920826 (day3), GSM920827 (day4), GSM920828 (day7), GSM920829 (day21)). (F) Expression of miR-221 and miR-222 during mouse skeletal muscle regeneration. (G) Expression of miR-221, miR-222 and ESR1 in TA muscle of no GEN-treated and GEN-treated mice at 21 days of injury. (D,F,G) n = 3. * p < 0.05.