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. 2022 Nov 3;23(21):13482. doi: 10.3390/ijms232113482

Figure 4.

Figure 4

Effects of GEN and miR-221/222 family on myoblast proliferation. (A,B) EdU staining (A) and counting (B) of C2C12 myoblasts after different treatments. miR-221 mimic (221 M), miR-222 mimic (222 M), miR-221 inhibitor (221 I), miR-222 inhibitor (222 I), GEN (Gen), GEN + miR-221 mimic (G221 M) and GEN + miR-222 mimic (G222 M). (C–G) Expression of miR-222 (C), miR-221 (D), BTG2 (E), CCNB (F) and CCND (G) in C2C12 myoblasts after different treatments. (H) Histological sections of TA muscle at 3 days after injury from GEN-treated (Gen-CTX, start treatment 3 days before muscle injury) and no GEN-treated mice (CTX). n = 3. * p < 0.05, compared with the NC group, # p < 0.05, compared with 222 M group, $ p < 0.05, compared with 221 M group.