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. 2022 Oct 29;23(21):13146. doi: 10.3390/ijms232113146

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Predominant effects of decline in Arylsulfatase B (ARSB) in mammalian cells. Decline in ARSB leads to profound effects on vital cell processes in mammalian cells, as indicated in this report. C4S = chondroitin 4-sulfate; DS = dermatan sulfate; EMT = epithelial-mesenchymal transition; CHST = chondroitin sulfotransferase; ERK = extracellular-signal regulated kinase; MAPK = mitogen- activated protein kinase; JNK = c-Jun N-terminal kinase; SHP2 = tyrosine-protein phosphatase non-receptor type 11.