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The thrombolytic effect of spermine NONOate+ UTMD. (A) Femoral blood flow velocity in control animals, (B) 24 h after thrombus formation without treatment, (C) 24 h after thrombus formation and free spermine NONOate treatment, and (D) 24 h after thrombus formation and spermine-NONOate-loaded microbubble and US stimulus treatments. Each trace or picture represents one experiment with 5 animals.
