FIG. 4.
Neutralization of IFN-γ and IL-12 in E. cuniculi-infected mice. (A) C57BL/6 mice (six per group) were infected i.p. with 107 spores of E. cuniculi and treated with antibody to IFN-γ (3 mg/mouse) weekly at 2 days prior to infection. The control animals were injected with an equal amount of rat IgG (RIgG). (B) C57BL/6 mice (six per group) were treated with 0.5 mg of goat anti-mouse IL-12 twice weekly beginning two days prior to infection or an equal volume of goat IgG (GIgG). The animals were observed daily for morbidity or mortality. The study was performed twice, with similar results.