Table 1.

Unresolved Issues in Established Indications for oral anticoagulation with potential indication for antiFXI.

Medical Condition	Unresolved Issues
Atrial fibrillation	End-stage renal disease (ClCR < 15 mL/min) Elderly patients (age ≥ 85 years) Concomitant acute coronary syndrome Concomitant heart valvular prothesis Medical devices Resumption of anticoagulation after major bleeding
Venous thromboembolism	End-stage renal disease Patients with gastro-intestinal or genito-urinary cancer Drug-drug interactions Antiphospholipid antibody syndrome

ClCR: creatinine clearence.