Table 5.
Plasma pharmacokinetic parameters of BAY 1831865. Geometric Mean (Geometric Mean CV%) BAY 1831865 PK parameters. For Tmax, data are presented as median (min-max). Data are from Nowotny B. et al. [26]. Cmax: Maximum plasma concentration; Tmax: time to reach Cmax. AUC: area under the curve; AUC/D: ratio of AUC and dose; T1/2: half-life time; Vd: volume of distribution; CL: clearance.
| Parameter | BAY 1831865 150 mg i.v. | BAY 1831865 150 mg s.c |
|---|---|---|
| Cmax (mg/L) | 48.3 (9.47) | 10.9 (67.4) |
| Tmax (h) | 1.94 (1.00–3.95) | 96.0 (48–239) |
| AUC (h × µg/mL) | 10.900 (16.7) | 5160 (61.1) |
| AUC/D (h /L) | 72.9 (16.7) | 34.4 (61.1) |
| T1/2 (h) | 208 (19.8) | 217 (36.5) |
| Vd (L) | 0.0137 (16.7) | 0.0291 (61.1) |
| CL (L/h) | 0.0137 (16.7) | 0.0291 (61.1) |