Table 7.
Plasma pharmacokinetic parameters of asundexian. Geometric Mean (Geometric Mean CV%) asundexian PK parameters. For Tmax, data are presented as median (min-max). Data are from Thomas, D et al. [29]. Cmax: Maximum plasma concentration; Tmax: time to reach Cmax. AUC: area under the curve; T1/2: half-life time.
| Parameter | Asundexian Oral Solution | Asundexian Tablets | ||||
|---|---|---|---|---|---|---|
| 5 mg | 12.5 mg | 25 mg | 25 mg | 50 mg | 100 mg | |
| Cmax (μg/L) | 91.4 (15.9) | 205 (19.1) | 372 (13.5) | 320 (18.3) | 617 (15.6) | 1230 (25.9) |
| AUC (h·ng/mL) | 1570 (18.8) | 3770 (24.9) | 6630 (25.4) | 5940 (19.9) 13 | 200 (16.1) | 27 600 (23.5) |
| Tmax (h) | 1.0 (0.75–1.50) | 1.0 (0.75–1.50) | 1.0 (0.75–1.50) | 2.5 (1.0–6.0) | 3.0 (1.0–4.0) | 3.0 (0.8–6.0) |
| T1/2 (h) | 14.5 (15.7) | 16.0 (18.1) | 15.2 (21.6) | 14.2 (20.0) | 17.4 (12.4) | 16.3 (13.7) |