Table 8.
Plasma pharmacokinetic parameters of milvexian. Geometric Mean (Geometric Mean CV%) milvexian PK parameters. For Tmax, data are presented as median (min-max). Data are from Perera, V et al. [33]. Cmax: Maximum plasma concentration; Tmax: time to reach Cmax. AUC: area under the curve; T1/2: half-life time.
| Parameter | Milvexian 20 mg Fasted |
Milvexian 60 mg Fasted |
Milvexian 200 mg Fasted |
Milvexian 200 mg Fed |
Milvexian 300 mg Fasted |
Milvexian 500 mg Fasted |
Milvexian 500 mg Fed |
|---|---|---|---|---|---|---|---|
| Cmax (ng/mL) | 126 (36.7) | 337 (23.6) | 1068 (98.6) | 1639 (20.9) | 1017 (34.1) | 1853 (32.0) | 3359 (39.6) |
| AUC (ng·h/mL) | 1220 (20.3) | 3793 (13.7) | 12,471 (68.0) | 17,811 (19.4) | 14,588 (29.9) | 20,991 (26.8) | 44,330 (25.0) |
| Tmax, (h) | 3.0 (1.0–4.0) | 3.0 (2.0–4.0) | 3.0 (2.0–4.0) | 4.0 (3.0–6.0) | 3.0 (2.0–4.0) | 3.0 (2.0–4.0) | 4.0 (4.0–6.0) |
| T1/2 (h) | 8.3 (17.0) | 9.9 (13.7) | 10.5 (28.8) | 9.0 (16.1) | 13.8 (21.0) | 12.2 (14.4) | 10.7 (12.1) |