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PK parameters of fesomersen after repeated doses of 200 mg and 300 mg twice weekly for 15 days then weekly for 78 days. Data are from Walsh, M. et al. [38]. Data are presented as geometric mean (geometric % CV). NA: not available. Cmax: Maximum plasma concentration; T1/2: half-life time.
| Parameter | 200 mg/Kg Fesomersen | 300 mg/Kg Fesomersen | ||
|---|---|---|---|---|
| (Day 1) | (Day 78) | (Day 1) | (Day 78) | |
| Cmax (μg/mL) | 8.24 (42.0) | 10.3 (36.8) | 14.3 (46.5) | 12.3 (41.1) |
| T1/2 (h) | NA | 16.9 (39.9) | NA | 13.1 (35.1) |
